Castration-resistant prostate cancer (CRPC)

This describes a prostate cancerProstate Cancer Prostate cancer is cancer of the prostate. Prostate cancer is the second most common cancerous tumor worldwide and is the fifth leading cause of cancer-related mortality among men. The prostate is a gland in the male reproductive system that surrounds the urethra just below the bladder. that grows despite decreasing the patient’s testosteroneTestosterone A male sex hormone that is produced mainly in the testicles. Amongst other effects, it regulates activity and growth of the prostate gland, and prostate cancer cells often need it to grow (see hormone-sensitive prostate cancer). levels through hormone therapyHormone therapy Also called Androgen Deprivation Therapy (ADT), this therapy either reduces the levels of male hormones (testosterone) from the body, or blocks its effects on prostate cancer cells. It can be drug-based or achieved by surgically removing the testicles ("orchiectomy").. It might still respond to and stop growing under an advanced “next generation” hormone therapyHormone therapy Also called Androgen Deprivation Therapy (ADT), this therapy either reduces the levels of male hormones (testosterone) from the body, or blocks its effects on prostate cancer cells. It can be drug-based or achieved by surgically removing the testicles ("orchiectomy"). (typically abirateroneAbiraterone (Zytiga®) A type of hormone treatment that reduces testosterone levels in the body, used in combination with prednisone to treat metastatic prostate cancer. or enzalutamideEnzalutamide (Xtandi®) A treatment that stops testosterone from reaching prostate cancer cells in the body, used to treat metastatic prostate cancer.).